Located in the heart of Iowa, the Presbytery of Des Moines spans the state from Sigourney in the east to Atlantic in the west, and from Perry south to the Iowa-Missouri border. Rolling hills, rich farmland, welcoming small towns and bustling cities define the region, known nationwide for its extensive agribusiness and insurance industries, quality education, and honest, hard-working residents. Concerts, museums, sporting events, bike trails, and more than a dozen institutions of higher learning all serve to enhance the quality of life in south central Iowa.

At the crossroads of two major interstate highways, I-35 and I-80, the presbytery office is located in Iowa's capital city of Des Moines, facilitating travel to the presbytery's 61 churches. Ranging in size from 20 members to 1,300 members, the congregations combined represent a total of 8,666 Presbyterians. The Des Moines Presbytery, offers unique opportunities for leadership and fellowship found in the heart of Iowa.